I've seen off the brothers -- how many people can come down sick with some kind of brain fever in one novel? Read an old piece on it by Somerset Maughan who calls out all its manifold faults but still regards it as a great masterpiece. True enough.
Middlemarch is different in every way except length, so I am taking a break by re-reading The Midnight Bell, the first volume of Patrick Hamilton's 20,000 Streets Under the Sky trilogy. Hamilton is best known for his stage thrillers, and the movies based on them, Rope and Gas Light. In his novels, however, he is just one of the funniest writers there is, even when his stories are kind of sad as they usually are. This is also a great London novel; Hamilton knows the West End and its pubs intimately.
I think I've read almost all his novels twice, Slaves of Solitude more than that.